Two adjacent AP-1-like binding sites form the electrophile-responsive element of the murine glutathione S-transferase Ya subunit gene.

@article{Friling1992TwoAA,
  title={Two adjacent AP-1-like binding sites form the electrophile-responsive element of the murine glutathione S-transferase Ya subunit gene.},
  author={R. S. Friling and Svetlana Bergelson and V Harburg Daniel},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1992},
  volume={89 2},
  pages={
          668-72
        }
}
An electrophile-responsive element (EpRE) in the 5' flanking region of the mouse glutathione S-transferase Ya subunit gene was recently found to be responsible for the induction of gene expression by xenobiotics that contain or acquire by metabolism an electrophilic center. We now find that this EpRE is composed of two adjacent 9-base-pair motifs related in sequence to the AP-1 binding site, a transcriptional enhancer originally identified as the phorbol 12-myristate 13-acetate (PMA) response… CONTINUE READING
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