Two Waves of Nuclear Factor κb Recruitment to Target Promoters

  title={Two Waves of Nuclear Factor κb Recruitment to Target Promoters},
  author={Simona Saccani and Serafino Pantano and Gioacchino Natoli},
  journal={The Journal of Experimental Medicine},
  pages={1351 - 1360}
Proinflammatory stimuli induce the rapid and transient translocation of nuclear factor (NF)-kappaB to the nucleus, where it activates transcription from several genes, including those encoding inflammatory cytokines and chemokines, adhesion molecules, and cytoprotective proteins. Using chromatin immunoprecipitation, we show that after an acute stimulation two distinct waves of NF-kappaB recruitment to target promoters occur: a fast recruitment to constitutively and immediately accessible (CIA… CONTINUE READING


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What does “ chromatin remodeling ” mean ?

  • R. D. Kornberg, Y. Lorch
  • Trends Biochem . Sci .
  • 2000

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