Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control.

@article{Loewith2002TwoTC,
  title={Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control.},
  author={Robbie Loewith and Estela Jacinto and Stephan Wullschleger and Anja Lorberg and Jos{\'e} L Crespo and D{\'e}bora Bonenfant and Wolfgang Oppliger and Paul Jenoe and Michael N. Hall},
  journal={Molecular cell},
  year={2002},
  volume={10 3},
  pages={457-68}
}
The target of rapamycin (TOR) proteins in Saccharomyces cerevisiae, TOR1 and TOR2, redundantly regulate growth in a rapamycin-sensitive manner. TOR2 additionally regulates polarization of the actin cytoskeleton in a rapamycin-insensitive manner. We describe two functionally distinct TOR complexes. TOR Complex 1 (TORC1) contains TOR1 or TOR2, KOG1 (YHR186c), and LST8. TORC2 contains TOR2, AVO1 (YOL078w), AVO2 (YMR068w), AVO3 (YER093c), and LST8. FKBP-rapamycin binds TORC1, and TORC1 disruption… CONTINUE READING
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