Two Strategies for Sequence Comparison: Profile-preprocessed and Secondary Structure-induced Multiple Alignment

@article{Heringa1999TwoSF,
  title={Two Strategies for Sequence Comparison: Profile-preprocessed and Secondary Structure-induced Multiple Alignment},
  author={Jaap Heringa},
  journal={Computers & chemistry},
  year={1999},
  volume={23 3-4},
  pages={341-64}
}
Multiple sequence alignment remains one of the most powerful tools for assessing sequence relateness and the identification of structurally and functionally important protein regions. In this work, two new techniques are introduced to increase the sensitivity of dynamic programming and to enable checks for alignment consistency: Profile-preprocessed and secondary structure-induced alignments. Both strategies are based upon the hierarchical dynamic programming technique and can be applied… CONTINUE READING