Two Pathways of Synaptic Vesicle Retrieval Revealed by Single-Vesicle Imaging

Abstract

Synaptic vesicle recycling is essential for maintaining efficient synaptic transmission. Detailed dissection of single-vesicle recycling still remains a major challenge. We have developed a fluorescent pH reporter that permits us to follow the fate of individual vesicles at hippocampal synapses after exocytosis. Here we show that, during low-frequency… (More)
DOI: 10.1016/j.neuron.2008.12.024

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