Two Parallel Pathways Assign Opposing Odor Valences during Drosophila Memory Formation.

@article{Yamazaki2018TwoPP,
  title={Two Parallel Pathways Assign Opposing Odor Valences during Drosophila Memory Formation.},
  author={D. Yamazaki and Makoto Hiroi and Takashi Abe and Kazumichi Shimizu and Maki Minami-Ohtsubo and Yuko Maeyama and Junjiro Horiuchi and Tetsuya Tabata},
  journal={Cell reports},
  year={2018},
  volume={22 9},
  pages={2346-2358}
}
During olfactory associative learning in Drosophila, odors activate specific subsets of intrinsic mushroom body (MB) neurons. Coincident exposure to either rewards or punishments is thought to activate extrinsic dopaminergic neurons, which modulate synaptic connections between odor-encoding MB neurons and MB output neurons to alter behaviors. However, here we identify two classes of intrinsic MB γ neurons based on cAMP response element (CRE)-dependent expression, γCRE-p and γCRE-n, which encode… CONTINUE READING
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