Two PDZ binding motifs within NS5 have roles in Tick-borne encephalitis virus replication.

@article{Melik2012TwoPB,
  title={Two PDZ binding motifs within NS5 have roles in Tick-borne encephalitis virus replication.},
  author={Wessam Melik and Karin Ellencrona and Michael Wigerius and Christer Hedstr{\"o}m and Annelie Elv{\"a}ng and Magnus Johansson},
  journal={Virus research},
  year={2012},
  volume={169 1},
  pages={54-62}
}
The flavivirus genus includes important human neurotropic pathogens like Tick-borne encephalitis virus (TBEV) and West-Nile virus (WNV). Flavivirus replication occurs at replication complexes, where the NS5 protein provides both RNA cap methyltransferase and RNA-dependent RNA polymerase activities. TBEVNS5 contains two PDZ binding motifs (PBMs) important for specific targeting of human PDZ proteins including Scribble, an association important for viral down regulation of cellular defense… CONTINUE READING
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