Two Orphan Seven-Transmembrane Segment Receptors Which Are Expressed in CD4-positive Cells Support Simian Immunodeficiency Virus Infection

@article{Farzan1997TwoOS,
  title={Two Orphan Seven-Transmembrane Segment Receptors Which Are Expressed in CD4-positive Cells Support Simian Immunodeficiency Virus Infection },
  author={Michael Farzan and Hyeryun Choe and Kathleen A. Martin and Luisa Marcon and Wolfgang Hofmann and Gunilla B. Karlsson and Ying Sun and Peter Barrett and Nathalie Marchand and Nancy Sullivan and Norma P. Gerard and Craig Gerard and Joseph Sodroski},
  journal={The Journal of Experimental Medicine},
  year={1997},
  volume={186},
  pages={405 - 411}
}
Clinical isolates of primate immunodeficiency viruses, including human immunodeficiency virus type 1 (HIV-1), enter target cells by sequential binding to CD4 and the chemokine receptor CCR5, a member of the seven-transmembrane receptor family. HIV-1 variants which use additional chemokine receptors are present in the central nervous system or emerge during the course of infection. Simian immunodeficiency viruses (SIV) have been shown to use CCR5 as a coreceptor, but no other receptors for these… CONTINUE READING
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