Two Novel Mutations and Predominant 35 delG Mutation in the Connexin 26 Gene ( GJB 2 ) in Iranian Populations *

@inproceedings{Chaleshtori2004TwoNM,
  title={Two Novel Mutations and Predominant 35 delG Mutation in the Connexin 26 Gene ( GJB 2 ) in Iranian Populations *},
  author={Morteza Hashemzadeh Chaleshtori and Mohsen Dowlati and Dd Farhud and Laleh Hoghooghi Rad and Roksana Sasanfar and Ali Hoseinipour and Mostafa Montazer Zohour and A Tolooi and Mohsen Ghadami and H Pourjafari and K L Ma and Oshaghi and Ma Patton},
  year={2004}
}
Mutations in the GJB2 gene encoding Connexin 26 (Cx26) protein are a major cause for autosomal recessive non syndromic and sporadic deafness in many populations. In this study we have investigated the prevalence of the GJB2 gene mutations using nested PCR pre screening strategy and direct sequencing method. Two hundred and sixty autosomal recessive non syndromic and sporadic deaf subjects from 199 families in two provinces of Iran (Gilan and Khorasan) were studied. Altogether 14 different… CONTINUE READING

References

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Connexins and deafness Homepage, World Wide Web URL: http//www.iro.es/cx26deaf.htm1

R Rabionet, P Gasparani, X Estivill
  • 2002
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