Two Novel Ergtoxins, Blockers of K+-channels, Purified from the Mexican Scorpion Centruroides elegans elegans

@article{RestanoCassulini2008TwoNE,
  title={Two Novel Ergtoxins, Blockers of K+-channels, Purified from the Mexican Scorpion Centruroides elegans elegans},
  author={Rita Restano-Cassulini and Timoteo Olamendi‐Portugal and Fernando Z. Zamudio and Baltazar Becerril and Lourival Domingos Possani},
  journal={Neurochemical Research},
  year={2008},
  volume={33},
  pages={1525-1533}
}
Voltage-gated potassium channels of the ether-a-go-go related gene (ERG) family are implicated in many important cellular processes. Three such genes have been cloned (erg1, erg2 and erg3) and shown to be expressed in the central nervous system (CNS) of mammalians. This communication describes the isolation and characterization of two isoforms of scorpion toxin (CeErg4 and CeErg5, systematic nomenclature γ-KTx1.7 and γ-KTx1.8, respectively) that can discriminate the various subtypes of ERG… 

Interacting sites of scorpion toxin ErgTx1 with hERG1 K+ channels.

Toxin modulators and blockers of hERG K(+) channels.

Scorpion venom components that affect ion-channels function.

Arthropod toxins acting on neuronal potassium channels

Voltage-gated potassium channels (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

The 6TM family of K channels comprises the voltage-gated KV subfamilies, the EAG subfamily (which includes hERG channels), the Ca2+-activated Slo subfamily and the Ca1-activated SK subfamily, which possesses a pore-forming α subunit that comprise tetramers of identical subunits or of different subunits (heteromeric).

Characterization of Four Medically Important Toxins from Centruroides huichol Scorpion Venom and Its Neutralization by a Single Recombinant Antibody Fragment

The ability of scFv HV to neutralize different toxins is a significant achievement, considering the diversity of the species of Mexican venomous scorpions, so this scFV is a candidate to be part of a recombinant anti-venom against scorpion stings in Mexico.

Dissecting Toxicity: The Venom Gland Transcriptome and the Venom Proteome of the Highly Venomous Scorpion Centruroides limpidus (Karsch, 1879)

This study corroborates that, in the venom of toxic buthid scorpions, the more abundant and diverse components are ion channel-acting toxins, mainly NaScTx, while they lack the HDP diversity previously demonstrated for the non-buthid scorpions.

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Novel alpha-KTx peptides from the venom of the scorpion Centruroides elegans selectively blockade Kv1.3 over IKCa1 K+ channels of T cells.

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