Two North American families with hereditary papillary renal carcinoma and identical novel mutations in the MET proto-oncogene.

@article{Schmidt1998TwoNA,
  title={Two North American families with hereditary papillary renal carcinoma and identical novel mutations in the MET proto-oncogene.},
  author={Laura S. Schmidt and K. W. Junker and Gregor Weirich and Gladys Glenn and Peter L. Choyke and Irina A. Lubensky and Zhengping Zhuang and Mike Jeffers and George Vande Woude and Hartmut Neumann and M. M. Walther and W. Marston Linehan and Berton Zbar},
  journal={Cancer research},
  year={1998},
  volume={58 8},
  pages={1719-22}
}
Hereditary papillary renal carcinoma (HPRC) is a newly recognized inherited disorder characterized by a predisposition to develop multiple bilateral papillary renal carcinomas. Individuals affected with HPRC have been shown to have germ-line mutations in the tyrosine kinase domain of the MET proto-oncogene. We identified a novel mutation in exon 16 of the MET gene in two large North American HPRC families. The H1112R MET mutation segregated with the disease, was not present in 320 normal… CONTINUE READING