Two New Hydronaphthoquinones from Sinningia aggregata (Gesneriaceae) and Cytotoxic Activity of Aggregatin D

  title={Two New Hydronaphthoquinones from Sinningia aggregata (Gesneriaceae) and Cytotoxic Activity of Aggregatin D},
  author={Maria Helena Verdan and Lauro Mera de Souza and Jo{\~a}o Ernesto de Carvalho and D{\'e}bora B. Vendramini Costa and Marcos Jos{\'e} Salvador and Andersson Barison and Maria {\'E}lida Alves Stefanello},
  journal={Chemistry \& Biodiversity},
Two new hydronaphthoquinones, aggregatins E and F (1 and 2, resp.) were isolated from the tubers of Sinningia aggregata (Ker‐Gawl.) Wiehler (Gesneriaceae), along with twelve known compounds aggregatin D (3), tectoquinone (4), 1‐hydroxy‐2‐methylanthraquinone (5), icosyl ferulate (6), pustuline (7), 1,6‐dihydroxy‐2‐methylanthranquinone (8), 6‐hydroxy‐2‐methylanthraquinone (9), 7‐hydroxy‐2‐methylanthraquinone (10), tyrosol (11), halleridone (12), calceolarioside B (13), and cornoside (14). All… 
11 Citations

Naphthochromenes and Related Constituents from the Tubers of Sinningia allagophylla.

6-Methoxy-7,8-benzocoumarin (6) has been isolated for the first time from a natural source.

Naphthoquinones of Sinningia reitzii and Anti-inflammatory/Antinociceptive Activities of 8-Hydroxydehydrodunnione.

Results suggest that this new naphthoquinone exhibits important anti-inflammatory and antinociceptive activities, which is dissimilar to that of most known analgesics.

Secondary metabolites from the leaves of Juglans regia L.

Two New Hydronaphthoquinones from Sinningia aggregata (Gesneriaceae) and Cytotoxic Activity of Aggregatin D.

Two new hydronaphthoquinones, aggregatins E (Ia) and F (Ib), along with twelve known compounds including cytotoxic aggregation D are isolated and structure elucidation are revealed.

Hypoglycemic Activity of Aqueous Extract of Latex from Hancornia speciosa Gomes: A Study in Zebrafish and In Silico

The results show a hypoglycemic activity of the extract in vivo, with no apparent toxicity, and computational studies suggest this could be at least partially due to the presence of bornesitol, since inositols can interact with carbohydrates’ enzymes.



Anthraquinone derivatives from Heterophyllaea pustulata.

From the leaves of Heterophyllaea pustulata two new monomeric anthraquinones and three known flavonoids, quercetin, isoquercitrin, and quercETin-3-O-beta-d-glucosyl-6' '-acetate, were obtained.

Lactones and quinones from the tubers of Sinningia aggregata.

Three new aromatic epsilon-lactones, aggregatins A, B, and C, a new naphthoquinone derivative, aggregatin D, and three known anthraquinones were isolated from the tubers of Sinningia aggregata and showed marginal antimicrobial activity.

The mutagenic constituents of Rubia tinctorum.

The results suggested that the greatest activity is exhibited by 1,3-dihydroxyanthraquinones possessing methyl or hydroxylmethyl group on carbon 2.

Formation of benzoquinol moiety in cornoside by salidroside mono-oxygenase, a cytochrome P450 enzyme, from Abeliophyllum distichum cell suspension cultures

The benzoquinol ring formation mechanism is discussed in comparison to the mechanism for ipso substitution of 4-hydroxybenzoate by active oxygen species followed by elimination leading to hydroquinone.

Composição do óleo essencial de Sinningia aggregata

The essential oil isolated by hydrodistillation from the aerial parts of Sinningia aggregata (Ker. Gawl.) Wiehler (Gesneriaceae) was analyzed by capillary GC and GC/MS. Seventeen components were

Anthraquinones from in vitro root culture of Morinda royoc L.

This is the first report on AQ production from root culture of this plant and the structures of isolated compounds were determined from 1H-NMR data.

New Anthraquinones from Rubia cordifolia Roots

Three new anthraquinones namely 1-hydroxy-2, 7-dimethylanthraquinone, 2-hydroxy-6-methylanthraquinone and 2, 6-dihydroxyanthraquinone along with n-nonadccane, n-heptadecane,