Two New Cyototoxic Cardenolides from the Whole Plants of Adonis multiflora Nishikawa & Koki Ito

  title={Two New Cyototoxic Cardenolides from the Whole Plants of Adonis multiflora Nishikawa \& Koki Ito},
  author={Jae-Woo Jung and Nam-In Baek and Jeon Hwang-Bo and Seung-Su Lee and Ji-Hae Park and kyeong-Hwa Seo and Jung-Hwa Kwon and Eun-Ji Oh and Dae-Young Lee and In Sik Chung and Myun-Ho Bang},
  pages={20823 - 20831}
A phytochemical investigation of the whole plants of Adonis multiflora Nishikawa & Koki Ito. resulted in the isolation and identification of two new cardenolides—adonioside A (1) and adonioside B (6)—as well as four known cardenolides: tupichinolide (2) oleandrine (3), cryptostigmin II (4), and cymarin (5). Their structures were elucidated on the basis of NMR, MS, and IR spectroscopic analyses. Compounds 1, 2, 5, and 6 showed significant cytotoxicity against six human cancer cell lines (HCT-116… Expand
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