Two New Alkaloidal Taxoids from the Needles of Taxus canadensis

@article{Shi2006TwoNA,
  title={Two New Alkaloidal Taxoids from the Needles of Taxus canadensis},
  author={Qingwen Shi and Xiao-Tang Si and Yong-ming Zhao and Xiao‐Hui Su and Xingzuo Li and Lolita O. Zamir and Teiko Yamada and Hiromasa Kiyota},
  journal={Bioscience, Biotechnology, and Biochemistry},
  year={2006},
  volume={70},
  pages={732 - 736}
}
Two new taxanes with a dimethylamino group on the C-5 side chain were identified for the first time in the needles of the Canadian yew, Taxus canadensis. Their structures were characterized as 7β,10β,13α-triacetoxy-5α-(3′-dimethylamino-3′-phenylpropanoyl)oxy-2α-hydroxy-2(3→20)abeotaxa-4(20),11-dien-9-one (1) and 2α,10β-diacetoxy-9α-hydroxy-5α-(3′-dimethylamino-3′-phenylpropanoyl)oxy-3,11-cyclotax-4(20)-en-13-one (2). 

Chemical Studies on Taxus canadensis

Findings establish the Canadian yew tree as significantly different from the remaining species as well as some chemical modifications on the taxanes isolated from this plant were carried out.

MALDI-MS of Pseudo-Alkaloid Taxanes from Taxus canadensis

Six previously reported taxanes with alkaloid side chains were isolated from the methanol extract of the needles of Taxus canadensis. The structures were established on the basis of 1D and 2D NMR

Natural taxanes: developments since 1828.

Natural Taxanes: Developments Since 1828 by Yu-Fang Wang, Qing-Wen Shi,* Mei Dong, Hiromasa Kiyota,* Yu-Cheng Gu, and Bin Cong is based on research conducted at the School of Pharmaceutical Sciences, Hebei Medical University.

Cardiotoxicity resulting from yew plant (Taxus canadensis) ingestion

A 48-year-old woman with a past medical history of depression presented to the emergency department after eating a handful of branches, leaves, and berries from a yew plant in a suicide attempt who recovered with supportive care.

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