Two Metabotropic γ-Aminobutyric Acid Receptors Differentially Modulate Calcium Currents in Retinal Ganglion Cells

@article{Zhang1997TwoM,
  title={Two Metabotropic γ-Aminobutyric Acid Receptors Differentially  Modulate Calcium Currents in Retinal Ganglion Cells },
  author={Jian wei Zhang and Wen Hong Shen and Malcolm M Slaughter},
  journal={The Journal of General Physiology},
  year={1997},
  volume={110},
  pages={45 - 58}
}
Metabotropic gamma-aminobutyric acid (GABA) receptors were studied in amphibian retinal ganglion cells using whole cell current and voltage clamp techniques. The aim was to identify the types of receptor present and their mechanisms of action and modulation. Previous results indicated that ganglion cells possess two ionotropic GABA receptors: GABAAR and GABACR. This study demonstrates that they also possess two types of metabotropic GABAB receptor: one sensitive to baclofen and another to cis… CONTINUE READING

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