Two MTHFR polymorphisms, maternal B-vitamin intake, and CHDs.

  title={Two MTHFR polymorphisms, maternal B-vitamin intake, and CHDs.},
  author={Lydi M W J van Driel and Anna C Verkleij-Hagoort and Robert de Jonge and Andr{\'e} G. Uitterlinden and Eric A. P. Steegers and Cornelia M van Duijn and R{\'e}gine P M Steegers-Theunissen},
  journal={Birth defects research. Part A, Clinical and molecular teratology},
  volume={82 6},
BACKGROUND The methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms are associated with complex congenital malformations. Whether these polymorphisms are associated with CHDs is not clear. We studied both MTHFR polymorphisms, folate and vitamin B2 by maternal food intake and supplements, and CHD risk. METHODS A case-control family study was conducted in a European population in the Netherlands including 230 case and 251 control children with both parents. Approximately… CONTINUE READING


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