Two LIM domain proteins and UNC-96 link UNC-97/pinch to myosin thick filaments in Caenorhabditis elegans muscle.

@article{Qadota2007TwoLD,
  title={Two LIM domain proteins and UNC-96 link UNC-97/pinch to myosin thick filaments in Caenorhabditis elegans muscle.},
  author={Hiroshi Qadota and Kristina B. Mercer and Rachel K. Miller and Kozo Kaibuchi and Guy M. Benian},
  journal={Molecular biology of the cell},
  year={2007},
  volume={18 11},
  pages={
          4317-26
        }
}
By yeast two-hybrid screening, we found three novel interactors (UNC-95, LIM-8, and LIM-9) for UNC-97/PINCH in Caenorhabditis elegans. All three proteins contain LIM domains that are required for binding. Among the three interactors, LIM-8 and LIM-9 also bind to UNC-96, a component of sarcomeric M-lines. UNC-96 and LIM-8 also bind to the C-terminal portion of a myosin heavy chain (MHC), MHC A, which resides in the middle of thick filaments in the proximity of M-lines. All interactions… CONTINUE READING
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