Two Insulin Gene Single Nucleotide Polymorphisms Associated with Type 1 Diabetes Risk in the Finnish and Swedish Populations

@inproceedings{Laine2007TwoIG,
  title={Two Insulin Gene Single Nucleotide Polymorphisms Associated with Type 1 Diabetes Risk in the Finnish and Swedish Populations},
  author={A P Laine and Hanna Holmberg and Anita Nilsson and Eva {\"O}rtqvist and M. Kiviniemi and Outi Vaarala and Hans K. Akerblom and Olli Simell and Mikael Knip and Johnny Ludvigsson and Sten-A. Ivarsson and Karin Larsson and {\AA}ke Lernmark and Jorma Ilonen},
  booktitle={Disease markers},
  year={2007}
}
We have developed high-throughput tests for the detection of the insulin gene region SNPs -23HphI and -2221MspI. The potential of these markers to enhance the efficiency of type 1 diabetes risk screening was then evaluated by analyzing them in Finnish and Swedish populations. Blood spots on filter paper were analyzed using PCR followed by sequence-specific hybridization and time-resolved fluorometry reading. Distribution of the genotypes at both positions differed significantly among the… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-8 of 8 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 23 references

C

B. J. Barratt, F. Payne, +9 authors C. Guja
Ionescu- Tirgoviste, D.E. Undlien, K.S. Ronningen, K.M. Gillespie, A.-P. Laine et al. / Two insulin gene single nucleotide polymorphisms associated with type 1 diabetes risk 145 E. Tuomilehto-Wolf, J. Tuomilehto, S.T. Bennett, D.G. Clayton, H.J. Cordell and J.A. Todd, Remapping the insulin gene/ID • 2004
View 4 Excerpts
Highly Influenced

Mapping disease genes: family-based association studies.

American journal of human genetics • 1995
View 3 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…