Two Independent Positive Feedbacks and Bistability in the Bcl-2 Apoptotic Switch

@article{Cui2008TwoIP,
  title={Two Independent Positive Feedbacks and Bistability in the Bcl-2 Apoptotic Switch},
  author={Jun Cui and Chun Chen and Haizhu Lu and Tingzhe Sun and Pingping Shen},
  journal={PLoS ONE},
  year={2008},
  volume={3},
  pages={489 - 506}
}
BACKGROUND The complex interplay between B-cell lymphoma 2 (Bcl-2) family proteins constitutes a crucial checkpoint in apoptosis. Its detailed molecular mechanism remains controversial. Our former modeling studies have selected the 'Direct Activation Model' as a better explanation for experimental observations. In this paper, we continue to extend this model by adding interactions according to updating experimental findings. METHODOLOGY/PRINCIPAL FINDINGS Through mathematical simulation we… CONTINUE READING
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