Two Feet on the Membrane: Uptake of Clostridial Neurotoxins.

@article{Rummel2016TwoFO,
  title={Two Feet on the Membrane: Uptake of Clostridial Neurotoxins.},
  author={Andreas Rummel},
  journal={Current topics in microbiology and immunology},
  year={2016},
  volume={406},
  pages={
          1-37
        }
}
The extraordinary potency of botulinum neurotoxins (BoNT) and tetanus neurotoxin (TeNT) is mediated by their high neurospecificity, targeting peripheral cholinergic motoneurons leading to flaccid and spastic paralysis, respectively, and successive respiratory failure. Complex polysialo gangliosides accumulate BoNT and TeNT on the plasma membrane. The ganglioside binding in BoNT/A, B, E, F, G, and TeNT occurs via a conserved ganglioside-binding pocket within the most carboxyl-terminal 25 kDa… CONTINUE READING
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