Two-Element Transcriptional Regulation in the Canonical Wnt Pathway

  title={Two-Element Transcriptional Regulation in the Canonical Wnt Pathway},
  author={K. Kim and J. Cho and Thomas S. Hilzinger and Harry Nunns and Andrew R. Liu and Bryan E. Ryba and Lea Goentoro},
  journal={Current Biology},
  • K. Kim, J. Cho, +4 authors Lea Goentoro
  • Published 2017
  • Biology, Medicine
  • Current Biology
  • The canonical Wnt pathway regulates numerous fundamental processes throughout development and adult physiology and is often disrupted in diseases [1-4]. Signal in the pathway is transduced by β-catenin, which in complex with Tcf/Lef regulates transcription. Despite the many processes that the Wnt pathway governs, β-catenin acts primarily on a single cis element in the DNA, the Wnt-responsive element (WRE), at times potentiated by a nearby Helper site. In this study, working with Xenopus, mouse… CONTINUE READING
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