Two E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis.

@article{Nishitani2006TwoEU,
  title={Two E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis.},
  author={Hideo Nishitani and Nozomi Sugimoto and Vassilis Roukos and Yohsuke Nakanishi and Masafumi Saijo and Chikashi Obuse and Toshiki Tsurimoto and Keiichi I Nakayama and Masatoshi Fujita and Zoi Lygerou and Takeharu Nishimoto},
  journal={The EMBO journal},
  year={2006},
  volume={25 5},
  pages={1126-36}
}
Replication licensing is carefully regulated to restrict replication to once in a cell cycle. In higher eukaryotes, regulation of the licensing factor Cdt1 by proteolysis and Geminin is essential to prevent re-replication. We show here that the N-terminal 100 amino acids of human Cdt1 are recognized for proteolysis by two distinct E3 ubiquitin ligases during S-G2 phases. Six highly conserved amino acids within the 10 first amino acids of Cdt1 are essential for DDB1-Cul4-mediated proteolysis… CONTINUE READING
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