Two Dobzhansky-Muller Genes Interact to Cause Hybrid Lethality in Drosophila

@article{Brideau2006TwoDG,
  title={Two Dobzhansky-Muller Genes Interact to Cause Hybrid Lethality in Drosophila},
  author={Nicholas J. Brideau and Heather A Flores and Jun Wang and Shamoni Maheshwari and Xu Wang and Daniel A. Barbash},
  journal={Science},
  year={2006},
  volume={314},
  pages={1292 - 1295}
}
The Dobzhansky-Muller model proposes that hybrid incompatibilities are caused by the interaction between genes that have functionally diverged in the respective hybridizing species. Here, we show that Lethal hybrid rescue (Lhr) has functionally diverged in Drosophila simulans and interacts with Hybrid male rescue (Hmr), which has functionally diverged in D. melanogaster, to cause lethality in F1 hybrid males. LHR localizes to heterochromatic regions of the genome and has diverged extensively in… Expand
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