Two Distinct Pathways for Targeting Proteins from the Cytoplasm to the Vacuole/Lysosome

  title={Two Distinct Pathways for Targeting Proteins from the Cytoplasm to the Vacuole/Lysosome},
  author={Misuzu Baba and Masako Osumi and Sidney V. Scott and Daniel J. Klionsky and Yoshinori Ohsumi},
  journal={The Journal of Cell Biology},
  pages={1687 - 1695}
Stress conditions lead to a variety of physiological responses at the cellular level. Autophagy is an essential process used by animal, plant, and fungal cells that allows for both recycling of macromolecular constituents under conditions of nutrient limitation and remodeling the intracellular structure for cell differentiation. To elucidate the molecular basis of autophagic protein transport to the vacuole/lysosome, we have undertaken a morphological and biochemical analysis of this pathway in… 

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