Two Distinct Pathways Support Gene Correction by Single-Stranded Donors at DNA Nicks.

@article{Davis2016TwoDP,
  title={Two Distinct Pathways Support Gene Correction by Single-Stranded Donors at DNA Nicks.},
  author={Luther Davis and Nancy Maizels},
  journal={Cell reports},
  year={2016},
  volume={17 7},
  pages={1872-1881}
}
Nicks are the most common form of DNA damage. The mechanisms of their repair are fundamental to genomic stability and of practical importance for genome engineering. We define two pathways that support homology-directed repair by single-stranded DNA donors. One depends upon annealing-driven strand synthesis and acts at both nicks and double-strand breaks. The other depends upon annealing-driven heteroduplex correction and acts at nicks. Homology-directed repair via these pathways, as well as… CONTINUE READING
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