Two Distinct Pathways Leading to Nuclear Apoptosis

@article{Susin2000TwoDP,
  title={Two Distinct Pathways Leading to Nuclear Apoptosis},
  author={Santos A Susin and Eric Daugas and Luigi Ravagnan and Kumiko Samejima and Naoufal Zamzami and Markus W Loeffler and Paola Costantini and Karine F. Ferri and Th{\'e}ano Irinopoulou and Marie-Christine Prevost and Greg M. Brothers and Tak W Mak and Josef M. Penninger and William C Earnshaw and Guido Kroemer},
  journal={The Journal of Experimental Medicine},
  year={2000},
  volume={192},
  pages={571 - 580}
}
Apaf-1(-/-) or caspase-3(-/-) cells treated with a variety of apoptosis inducers manifest apoptosis-associated alterations including the translocation of apoptosis-inducing factor (AIF) from mitochondria to nuclei, large scale DNA fragmentation, and initial chromatin condensation (stage I). However, when compared with normal control cells, Apaf-1(-/-) or caspase-3(-/-) cells fail to exhibit oligonucleosomal chromatin digestion and a more advanced pattern of chromatin condensation (stage II… CONTINUE READING

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