Two Distinct Integrin-Mediated Mechanisms Contribute to Apical Lumen Formation in Epithelial Cells

@inproceedings{Myllymki2011TwoDI,
  title={Two Distinct Integrin-Mediated Mechanisms Contribute to Apical Lumen Formation in Epithelial Cells},
  author={Satu Marja Myllym{\"a}ki and Terhi Piritta Ter{\"a}v{\"a}inen and Aki Manninen},
  booktitle={PloS one},
  year={2011}
}
BACKGROUND Formation of apical compartments underlies the morphogenesis of most epithelial organs during development. The extracellular matrix (ECM), particularly the basement membrane (BM), plays an important role in orienting the apico-basal polarity and thereby the positioning of apical lumens. Integrins have been recognized as essential mediators of matrix-derived polarity signals. The importance of β1-integrins in epithelial polarization is well established but the significance of the… CONTINUE READING
16 Citations
56 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 16 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 56 references

Integrin alpha3beta1dependent beta-catenin phosphorylation links epithelial smad signaling to cell contacts

  • Y Kim, MC Kugler, Y Wei, KK Kim, X Li
  • J Cell Biol
  • 2009

Similar Papers

Loading similar papers…