Two Classes of Bacterial IMPDHs according to Their Quaternary Structures and Catalytic Properties

@inproceedings{Alexandre2015TwoCO,
  title={Two Classes of Bacterial IMPDHs according to Their Quaternary Structures and Catalytic Properties},
  author={Thomas Alexandre and Bertrand Rayna and H{\'e}l{\'e}ne Munier-Lehmann},
  booktitle={PloS one},
  year={2015}
}
Inosine-5'-monophosphate dehydrogenase (IMPDH) occupies a key position in purine nucleotide metabolism. In this study, we have performed the biochemical and physico-chemical characterization of eight bacterial IMPDHs, among which six were totally unexplored. This study led to a classification of bacterial IMPDHs according to the regulation of their catalytic properties and their quaternary structures. Class I IMPDHs are cooperative enzymes for IMP, which are activated by MgATP and are octameric… CONTINUE READING

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