Two Ca2+ entry pathways mediate InsP3-sensitive store refilling in guinea-pig colonic smooth muscle.

@article{McCarron2000TwoCE,
  title={Two Ca2+ entry pathways mediate InsP3-sensitive store refilling in guinea-pig colonic smooth muscle.},
  author={John G. McCarron and Elaine R M Flynn and Karen N. Bradley and Thomas C. Muir},
  journal={The Journal of physiology},
  year={2000},
  volume={525 Pt 1},
  pages={113-24}
}
Sarcolemma Ca2+ influx, necessary for store refilling, was well maintained, over a wide range (-70 to + 40 mV) of membrane voltages, in guinea-pig single circular colonic smooth muscle cells, as indicated by the magnitude of InsP3-evoked Ca2+ transients. This apparent voltage independence of store refilling was achieved by the activity of sarcolemma Ca2+ channels some of which were voltage gated while others were not. At negative membrane potentials (e.g. -70 mV), Ca2+ influx through channels… CONTINUE READING
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