Two Ca2+-Binding Sites Cooperatively Couple Together in TMEM16A Channel

@article{Han2015TwoCS,
  title={Two Ca2+-Binding Sites Cooperatively Couple Together in TMEM16A Channel},
  author={Yuebin Han and Suhua Zhang and Shuxi Ren and Yafei Chen and Hongbo Yuan and Ran Chai and Hui Yu and Hailin Zhang and Yong Zhan and Hailong An},
  journal={The Journal of Membrane Biology},
  year={2015},
  volume={249},
  pages={57-63}
}
TMEM16A is the molecular basis of calcium-activated chloride channels and shows Ca2+-dependent gating. It is critical to understand how the Ca2+ sensors dynamically control the gate of TMEM16A. However, the detailed mechanism by which the calcium ions bind and open the channel is still obscure. In this study, the authors confirmed that there are two Ca2+ sensors which cooperatively couple together in TMEM16A. Our data show that mutations at both Ca2+-sensitive domains, E447Y and E702Q-E705Q… CONTINUE READING