Two C. elegans genes control the programmed deaths of specific cells in the pharynx.

@article{Ellis1991TwoCE,
  title={Two C. elegans genes control the programmed deaths of specific cells in the pharynx.},
  author={Ronald E. Ellis and H Robert Horvitz},
  journal={Development},
  year={1991},
  volume={112 2},
  pages={591-603}
}
The genes ces-1 and ces-2 control the decisions of two cells in the nematode Caenorhabditis elegans to undergo programmed cell death. Mutations that cause a gain of ces-1 function or a reduction of ces-2 function prevent these cells, the sisters of the two pharyngeal NSM neurons, from dying. These mutations do not affect most other cell deaths. Genetic studies indicate that ces-1 and ces-2 affect the fates of the NSM sisters by regulating the genes required for all programmed cell deaths to… CONTINUE READING