Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages

@article{Matsunaga2009TwoB1,
  title={Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages},
  author={Kohichi Matsunaga and Tatsuya Saitoh and Keisuke Tabata and Hiroko Omori and Takashi Satoh and Naoki Kurotori and Ikuko Maejima and Kanae Shirahama-Noda and Tohru Ichimura and Toshiaki Isobe and Shizuo Akira and Takeshi Noda and Tamotsu Yoshimori},
  journal={Nature Cell Biology},
  year={2009},
  volume={11},
  pages={385-396}
}
Beclin 1, a protein essential for autophagy, binds to hVps34/Class III phosphatidylinositol-3-kinase and UVRAG. Here, we have identified two Beclin 1 associated proteins, Atg14L and Rubicon. Atg14L and UVRAG bind to Beclin 1 in a mutually exclusive manner, whereas Rubicon binds only to a subpopulation of UVRAG complexes; thus, three different Beclin 1 complexes exist. GFP–Atg14L localized to the isolation membrane and autophagosome, as well as to the ER and unknown puncta. Knockout of Atg14L in… CONTINUE READING
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