Two Abundant Bioaccumulated Halogenated Compounds Are Natural Products

  title={Two Abundant Bioaccumulated Halogenated Compounds Are Natural Products},
  author={Emma L. Teuten and Li Xu and Christopher M. Reddy},
  pages={917 - 920}
Methoxylated polybrominated diphenyl ethers (MeO-PBDEs) have been found bioaccumulated in the tissues of a variety of aquatic animals and at concentrations comparable to those of anthropogenic halogenated organic compounds, including polychlorinated biphenyls (PCBs). The origin of the MeO-PBDEs has been uncertain; circumstantial evidence supports a natural and/or an industrial source. By analyzing the natural abundance radiocarbon content of two MeO-PBDEs isolated from a True's beaked whale… 

Biosynthesis of polybrominated aromatic organic compounds by marine bacteria

Polybrominated diphenyl ethers (PBDEs) and polybrominated bipyrroles are natural products that bioaccumulate in the marine food chain. PBDEs have attracted widespread attention due to their

Marine halogenated natural products of environmental relevance.

  • W. Vetter
  • Chemistry, Environmental Science
    Reviews of environmental contamination and toxicology
  • 2006
A wide range and steadily increasing number of halogenated natural products (HNPs) is detected in marine organisms that are not the natural source of these compounds but which have accumulated these

Natural Production of Organohalide Compounds in the Environment

More than 5000 natural organohalogen compounds have been identified. In terrestrial environments, the bulk of the organochlorine is locked up in humic polymers, collectively accounting for a global

Enzymatic Synthesis of Polybrominated Dioxins from the Marine Environment

It is reported that the bmp gene locus in marine bacteria, a recently characterized source of polybrominated diphenyl ethers, can also synthesize dibenzo-p-dioxins by employing different phenolic initiator molecules.

Complexity of naturally produced polybrominated diphenyl ethers revealed via mass spectrometry.

Using mass spectrometry and NMR spectroscopy, the existence of new structural classes of PBDEs in marine sponges is established and this work expands the chemical space explored by naturally producedPBDEs, which may inform future environmental toxicology studies.

Food web bioaccumulation of organohalogenated compounds in high mountain lakes

Persistent organic pollutants (POPs) are toxic substances that are usually produced for use in agricultural, industrial, and domestic applications. Because of their long-range atmospheric transport

Concentrations of halogenated natural products versus PCB 153 in bivalves from the North and Baltic Seas.

Halogenated organic compounds in archived whale oil: a pre-industrial record.




Radiocarbon evidence for a naturally produced, bioaccumulating halogenated organic compound.

The presence of detectable 14C in the DBP-Br4Cl2 strongly points to at least a natural or biogenic source, however, these delta14C values for DBPs are more depleted than expected for a recently synthesized natural product.

Two new minor polybrominated dibenzo-p-dioxins from the marine sponge Dysidea dendyi.

Two new minor tribromodibenzo-p-dioxins, spongiadioxin C and its methyl ether, were isolated from an Australian marine sponge Dysidea dendyi and inhibited the cell division of fertilized sea urchin eggs.

Sponge halogenated natural products found at parts‐per‐million levels in marine mammals

The quantitative determination ofBC-2 in blubber of marine mammals from Africa and the Antarctic suggests that BC-2 is widespread, and is direct proof that marine biota can produce persistent organic chemicals that accumulate to substantial concentrations in higher trophic organisms.

Four new bioactive polybrominated diphenyl ethers of the sponge Dysidea herbacea from West Sumatra, Indonesia.

The marine sponge Dysidea herbacea collected from Indonesia yielded four new polybrominated diphenyl ether congeners 2-5 and the known derivatives 1, 6, and 7, which were active against the Gram-positive bacteria Bacillus subtilis and the phytopathogenic fungus Cladosporium cucumerinum.

Photochemical decomposition of 15 polybrominated diphenyl ether congeners in methanol/water.

The photochemical reaction rate decreased with decreasing number of bromine substituents in the molecule but also in some cases influenced by the PBDE substitution pattern, and the reaction rate was dependent on the solvent in such a way that the Reaction rate in a methanol/water solution was consistently around 1.7 times lower than in pure methanolate and 2-3 times lower in THF.

Identification and Quantification of Polybrominated Diphenyl Ethers and Methoxy-Polybrominated Diphenyl Ethers in Baltic Biota

Polybrominated diphenyl ethers (PBDPEs) and, for the first time, methoxy-polybrominated diphenyl ethers (MeO-PBDPEs) have been positively identified and quantified in various biotic samples including

Biodegradation of diphenyl ether and its monohalogenated derivatives by Sphingomonas sp. strain SS3

Formation of phenol, catechol, halophenol, and halocatechol from the conversion of monohalogenated diphenyl ethers gives evidence for a nonspecific attack of the dioxygenating enzyme system.

Enzyme inhibitors: new and known polybrominated phenols and diphenyl ethers from four Indo-Pacific Dysidea sponges.

Extracts and pure compounds isolated from four samples of Dysidea sp. sponges collected from two geographically distinct regions of the Indo-Pacific (Chuuk Atoll and Fiji) were assayed against five