Twisted tango: brain tumor neurovascular interactions

  title={Twisted tango: brain tumor neurovascular interactions},
  author={Anita B. Hjelmeland and Justin D Lathia and Sith Sathornsumetee and Jeremy Rich},
  journal={Nature Neuroscience},
The brain is a complicated organ with complexity derived from cellular and microenvironmental interactions. Similarly, brain tumor cells actively modify and are regulated by their microenvironment. Brain tumors are highly heterogeneous and frequently show a cellular hierarchy with self-renewing tumorigenic brain tumor stem cells (BTSCs) at the apex. Although BTSCs are distinct from neural stem cells, they share characteristics, including bidirectional interplay with supportive vasculature… CONTINUE READING
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