Twist2 regulates CD7 expression and galectin-1-induced apoptosis in mature T-cells.

  title={Twist2 regulates CD7 expression and galectin-1-induced apoptosis in mature T-cells.},
  author={Han Seok Koh and Changjin Lee and Kwang Soo Lee and Eun Jung Park and Rho Hyun Seong and Seokmann Hong and Sung Ho Jeon},
  journal={Molecules and cells},
  volume={28 6},
In the periphery, a galectin-1 receptor, CD7, plays crucial roles in galectin-1-mediated apoptosis of activated T-cells as well as progression of T-lymphoma. Previously, we demonstrated that NF-kappaB downregulated CD7 gene expression through the p38 MAPK pathway in developing immature thymocytes. However, its regulatory pathway is not well understood in functional mature T-cells. Here, we show that CD7 expression was downregulated by Twist2 in Jurkat cells, a human acute T-cell lymphoma cell… CONTINUE READING


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Twist as a new prognostic marker in hematological malignancies.

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