Twist1-induced dissemination preserves epithelial identity and requires E-cadherin

  title={Twist1-induced dissemination preserves epithelial identity and requires E-cadherin},
  author={Eliah R. Shamir and Elisa Pappalardo and Danielle M Jorgens and Kester Coutinho and Wen-Ting Tsai and Khaled Aziz and Manfred Auer and Phuoc T Tran and Joel S. Bader and Andrew J Ewald},
  booktitle={The Journal of cell biology},
Dissemination of epithelial cells is a critical step in metastatic spread. Molecular models of dissemination focus on loss of E-cadherin or repression of cell adhesion through an epithelial to mesenchymal transition (EMT). We sought to define the minimum molecular events necessary to induce dissemination of cells out of primary murine mammary epithelium. Deletion of E-cadherin disrupted epithelial architecture and morphogenesis but only rarely resulted in dissemination. In contrast, expression… CONTINUE READING
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Publications referenced by this paper.
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Twist is a transcriptional repressor of E-cadherin gene expression in breast cancer.

Biochemical and biophysical research communications • 2008
View 14 Excerpts
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HTSeq: Analysing high-throughput sequencing data with Python

S. Anders
Available at index.html (Accessed on December 26, 2012). • 2010
View 2 Excerpts
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Inactivation of the E-cadherin-mediated cell adhesion system in human cancers.

The American journal of pathology • 1998
View 6 Excerpts
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