Twist1-induced dissemination preserves epithelial identity and requires E-cadherin

@inproceedings{Shamir2014Twist1inducedDP,
  title={Twist1-induced dissemination preserves epithelial identity and requires E-cadherin},
  author={Eliah R. Shamir and Elisa Pappalardo and Danielle M Jorgens and Kester Coutinho and Wen-Ting Tsai and Khaled Aziz and Manfred Auer and Phuoc T Tran and Joel S. Bader and Andrew J Ewald},
  booktitle={The Journal of cell biology},
  year={2014}
}
Dissemination of epithelial cells is a critical step in metastatic spread. Molecular models of dissemination focus on loss of E-cadherin or repression of cell adhesion through an epithelial to mesenchymal transition (EMT). We sought to define the minimum molecular events necessary to induce dissemination of cells out of primary murine mammary epithelium. Deletion of E-cadherin disrupted epithelial architecture and morphogenesis but only rarely resulted in dissemination. In contrast, expression… CONTINUE READING
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