Twist-open mechanism of DNA damage recognition by the Rad4/XPC nucleotide excision repair complex.

Abstract

DNA damage repair starts with the recognition of damaged sites from predominantly normal DNA. In eukaryotes, diverse DNA lesions from environmental sources are recognized by the xeroderma pigmentosum C (XPC) nucleotide excision repair complex. Studies of Rad4 (radiation-sensitive 4; yeast XPC ortholog) showed that Rad4 "opens" up damaged DNA by inserting a… (More)
DOI: 10.1073/pnas.1514666113

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