Twist is up-regulated in response to Wnt1 and inhibits mouse mammary cell differentiation.

  title={Twist is up-regulated in response to Wnt1 and inhibits mouse mammary cell differentiation.},
  author={Louise R. Howe and Osamu Watanabe and James Leonard and Anthony M. C. Brown},
  journal={Cancer research},
  volume={63 8},
Wnt1, initially identified as a mammary oncogene, can activate transcription via beta-catenin/TCF complexes. Twist, a transcription factor of the basic helix-loop-helix class, has also been suggested to have oncogenic properties. The aim of this study was to determine whether Twist is regulated by Wnt1 and might thus be a novel mediator of Wnt signaling. We found that Twist was up-regulated in C57MG and HC11 murine mammary epithelial cells in response to Wnt1 expression. Additionally, we… CONTINUE READING


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