Twist is a potential oncogene that inhibits apoptosis.

@article{Maestro1999TwistIA,
  title={Twist is a potential oncogene that inhibits apoptosis.},
  author={Roberta Maestro and Angelo P Dei Tos and Yasuo Hamamori and Svetlana Krasnokutsky and Vittorio Sartorelli and L. Kedes and Claudio Doglioni and David H. Beach and Gregory J Hannon},
  journal={Genes & development},
  year={1999},
  volume={13 17},
  pages={2207-17}
}
Oncogene activation increases susceptibility to apoptosis. Thus, tumorigenesis must depend, in part, on compensating mutations that protect from programmed cell death. A functional screen for cDNAs that could counteract the proapoptotic effects of the myc oncogene identified two related bHLH family members, Twist and Dermo1. Both of these proteins inhibited oncogene- and p53-dependent cell death. Twist expression bypassed p53-induced growth arrest. These effects correlated with an ability of… CONTINUE READING
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Genetics in mammalian cells

  • klin, D. Beach
  • 1999

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