Twist genes regulate Runx2 and bone formation.

Abstract

Runx2, a master regulator of osteoblast differentiation, is expressed several days before osteoblast genes in bone anlage. In this issue of Developmental Cell, show that Twist-1 and Twist-2 suppress the activity of Runx2 and thereby regulate bone formation.

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@article{Kronenberg2004TwistGR, title={Twist genes regulate Runx2 and bone formation.}, author={Henry M . Kronenberg}, journal={Developmental cell}, year={2004}, volume={6 3}, pages={317-8} }