Twist-Bend Coupling and the Torsional Response of Double-Stranded DNA.

@article{Nomidis2016TwistBendCA,
  title={Twist-Bend Coupling and the Torsional Response of Double-Stranded DNA.},
  author={Stefanos K. Nomidis and Franziska Kriegel and Willem Vanderlinden and Jan Lipfert and Enrico Carlon},
  journal={Physical review letters},
  year={2016},
  volume={118 21},
  pages={
          217801
        }
}
Recent magnetic tweezers experiments have reported systematic deviations of the twist response of double-stranded DNA from the predictions of the twistable wormlike chain model. Here we show, by means of analytical results and computer simulations, that these discrepancies can be resolved if a coupling between twist and bend is introduced. We obtain an estimate of 40±10  nm for the twist-bend coupling constant. Our simulations are in good agreement with high-resolution, magnetic-tweezers torque… 
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Twist-bend coupling and the statistical mechanics of DNA: perturbation theory and beyond

A perturbative calculation of the effective torsional stiffness Ceff for small twist-bend coupling finds that the “bare” G is “screened” by thermal fluctuations, in the sense that the low-force, long-molecule effective free energy is that of a model with G = 0, but with long-wavelength bending and twisting rigidities that are shifted by G-dependent amounts.

Twist-bend coupling, twist waves, and the shape of DNA loops.

This work investigates the minimal-energy shape of short DNA loops of approximately 100 base pairs and shows that in these loops the excess twist density oscillates as a response to an imposed bending stress, as recently found in DNA minicircles and observed in nucleosomal DNA.

Twist-bend coupling and the statistical mechanics of the twistable wormlike-chain model of DNA: Perturbation theory and beyond.

A perturbative calculation of the effective torsional stiffness C_{eff} for small twist-bend coupling finds that the "bare" G is "screened" by thermal fluctuations, in the sense that the low-force, long-molecule effective free energy is that of a model with G=0 but with long-wavelength bending and twisting rigidities that are shifted by G-dependent amounts.

DNA elasticity from coarse-grained simulations: The effect of groove asymmetry.

By performing computer simulations of two available versions of oxDNA, a coarse-grained model of nucleic acids, the microscopic origin of twist-bend coupling is investigated, and it is shown that this interaction is negligible in the oxDNA version with symmetric grooves, while it appears in theOx DNA version with asymmetric groves.

Dynamics of the Buckling Transition in Double-Stranded DNA and RNA.

Twist dynamics and buckling instability of ring DNA: the effect of groove asymmetry and anisotropic bending.

The mapping of the realistic DNA model to the simpler isotropic twistable worm-like chain using the renormalized bending and twist moduli is discussed; although useful in many cases, it fails to make a quantitative prediction on the instability mode of buckling transition.

Twist-diameter coupling drives DNA twist changes with salt and temperature

DNA deformations upon environmental changes, e.g., salt and temperature, play crucial roles in many biological processes and material applications. Here, our magnetic tweezers experiments observed…

DNA polygons

The calculation of the twist and bending energy of minicircles shows how these are governed by renormalized stiffness constants, not the bare ones, which has important consequences for the analysis of experiments involving circular DNA meant to determine DNA elastic constants.

Computing the Elastic Mechanical Properties of Rodlike DNA Nanostructures.

The obtained bending persistence lengths are much larger than that for double-stranded DNA and increase nonlinearly with the number of helices, whereas the twist moduli increase approximately linearly, and the twist-bend coupling constants are of order zero.

Length-scale-dependent elasticity in DNA from coarse-grained and all-atom models.

Analysis of both coarse-grained (oxDNA) and all-atom models indicates that there are strong off-site couplings for tilt-tilt and twist-twist, while they are much weaker in the roll-roll case.
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