Twist: a molecular target in cancer therapeutics

@article{Khan2013TwistAM,
  title={Twist: a molecular target in cancer therapeutics},
  author={Md Asaduzzaman Khan and Han-chun Chen and Dianzheng Zhang and Junjiang Fu},
  journal={Tumor Biology},
  year={2013},
  volume={34},
  pages={2497-2506}
}
Twist, the basic helix-loop-helix transcription factor, is involved in the process of epithelial to mesenchymal transitions (EMTs), which play an essential role in cancer metastasis. Overexpression of Twist or its promoter methylation is a common scenario in metastatic carcinomas. Twist is activated by a variety of signal transduction pathways, including Akt, signal transducer and activator of transcription 3, mitogen-activated protein kinase, Ras, and Wnt signaling. Activated Twist upregulates… CONTINUE READING
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