Twin priming: a proposed mechanism for the creation of inversions in L1 retrotransposition.

@article{Ostertag2001TwinPA,
  title={Twin priming: a proposed mechanism for the creation of inversions in L1 retrotransposition.},
  author={Eric M. Ostertag and Haig H. Kazazian},
  journal={Genome research},
  year={2001},
  volume={11 12},
  pages={2059-65}
}
L1 retrotransposons are pervasive in the human genome. Approximately 25% of recent L1 insertions in the genome are inverted and truncated at the 5' end of the element, but the mechanism of L1 inversion has been a complete mystery. We analyzed recent L1 inversions from the genomic database and discovered several findings that suggested a mechanism for the creation of L1 inversions, which we call twin priming. Twin priming is a consequence of target primed reverse transcription (TPRT), a coupled… CONTINUE READING

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