Twin RNA Polymerase–Associated Proteins Control Virulence Gene Expression in Francisella tularensis

@article{Charity2007TwinRP,
  title={Twin RNA Polymerase–Associated Proteins Control Virulence Gene Expression in Francisella tularensis},
  author={James Carl Charity and Michelle M. Costante-Hamm and Emmy L Balon and Dana H Boyd and Eric J. Rubin and Simon L. B. Dove},
  journal={PLoS Pathogens},
  year={2007},
  volume={3},
  pages={631 - 646}
}
The MglA protein is the only known regulator of virulence gene expression in Francisella tularensis, yet it is unclear how it functions. F. tularensis also contains an MglA-like protein called SspA. Here, we show that MglA and SspA cooperate with one another to control virulence gene expression in F. tularensis. Using a directed proteomic approach, we show that both MglA and SspA associate with RNA polymerase (RNAP) in F. tularensis, and that SspA is required for MglA to associate with RNAP… CONTINUE READING

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