Twice weekly prophylactic therapy in haemophilia A.

  title={Twice weekly prophylactic therapy in haemophilia A.},
  author={A Aronstam and P J Kirk and JOHN G. MCHARDY and J W Culver-James and David S. McLellan and Philippe Turk and S G Rainsford and Martha L. Slattery},
  journal={Journal of clinical pathology},
  volume={30 1},
Factor VIII-containing materials were administered to four severely affected haemophiliacs twice weekly in doses calculated to raise the factor VIII level to either 15% or 30% of average normal. The pooled results from those patients with statistically similar baseline bleeding frequencies showed a significant reduction in bleeding frequency on both doses in the first 48 hours. The 30% dose produced a more significant reduction than the 15% dose in the first 24 hours, but there was no… CONTINUE READING

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