Twenty years since the discovery of the parkin gene

@article{Hattori2017TwentyYS,
  title={Twenty years since the discovery of the parkin gene},
  author={Nobutaka Hattori and Yoshikuni Mizuno},
  journal={Journal of Neural Transmission},
  year={2017},
  volume={124},
  pages={1037-1054}
}
Nearly 20 years have passed since we identified the causative gene for a familial Parkinson’s disease, parkin (now known as PARK2), in 1998. PARK2 is the most common gene responsible for young-onset Parkinson’s disease. It codes for the protein Parkin RBR E3 ubiquitin-protein ligase (PARK2), which directly links to the ubiquitin-proteasome as a ubiquitin ligase. PARK2 is involved in mitophagy, which is a type of autophagy, in collaboration with PTEN-induced putative kinase 1 (PINK1). The PINK1… CONTINUE READING
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