Twenty years post‐NIH Revitalization Act: Enhancing minority participation in clinical trials (EMPaCT): Laying the groundwork for improving minority clinical trial accrual
@article{Chen2014TwentyYP, title={Twenty years post‐NIH Revitalization Act: Enhancing minority participation in clinical trials (EMPaCT): Laying the groundwork for improving minority clinical trial accrual}, author={Moon S Chen and Primo Nery Lara and Julie H T Dang and Debora A. Paterniti and Karen A. Kelly}, journal={Cancer}, year={2014}, volume={120} }
The National Institutes of Health (NIH) Revitalization Act of 1993 mandated the appropriate inclusion of minorities in all NIH‐funded research. Twenty years after this act, the proportion of minority patients enrolled in cancer clinical trials remains persistently low. Clinical trials are vehicles for the development and evaluation of therapeutic and preventive agents under scientifically rigorous conditions. Without representation in trials, it is projected that disparities in the cancer…
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References
SHOWING 1-10 OF 36 REFERENCES
The inclusion of women and minorities in smoking cessation clinical trials: a systematic review.
- MedicineThe American journal on addictions
- 2009
Female representation, while commensurate with population levels, declined significantly for trials that began recruitment after 1993, and minorities continued to be under-represented in later trials; however, significant improvement in representation and analysis by race occurred.
Increasing minority participation in cancer clinical trials: the minority-based community clinical oncology program experience.
- MedicineJournal of clinical oncology : official journal of the American Society of Clinical Oncology
- 2005
MBCCOPs have demonstrated their ability to facilitate the participation of racial/ethnic minorities in clinical trials, but the contributions that they could make to the design and conduct of minority-focused research studies merit further exploration.
Gender, Racial, and Ethnic Disclosure in NIH K-Award Funded Diabetes and Obesity Clinical Trials
- MedicineAccountability in research
- 2006
Overall, disclosure of race declined over the 3 timeframes whereas individually, the disclosure of African Americans improved, and clinical trials that focused on females increased across the3 timeframes for diabetes studies but not obesity studies.
Evaluating minority recruitment into clinical studies: how good are the data?
- MedicineAnnals of epidemiology
- 1997
Interpretations of 'appropriate' minority inclusion in clinical research.
- PsychologyThe American journal of medicine
- 2004
Barriers to therapeutic clinical trials enrollment: Differences between African-American and white cancer patients identified at the time of eligibility assessment
- MedicineClinical trials
- 2012
This study is the first to directly compare ineligibility and refusal rates and reasons captured prospectively in AA and White cancer patients, and is consistent with earlier studies that indicated that AA patients more often are deemed ineligible and, when eligible, more often refuse participation.
Overcoming barriers to cancer clinical trial accrual
- MedicineCancer
- 2008
An objective of the current study was to increase awareness of CCT and SB37 through a mass multimedia campaign (MMC) in the University of California (UC) Davis (UCD) Cancer Center catchment area.
Inclusion, analysis, and reporting of sex and race/ethnicity in clinical trials: have we made progress?
- MedicineJournal of women's health
- 2011
The current level of compliance with guidelines for the inclusion, analysis, and reporting of sex and race/ethnicity in federally funded randomized controlled trials (RCTs) is compared to that from 2004.
Why ethnic minority groups are under-represented in clinical trials: a review of the literature.
- Psychology, MedicineHealth & social care in the community
- 2004
A narrative review of the available literature, based mainly on US studies, aims to make sense of the issues around under-representation by providing a theoretical reconciliation and offers a number of strategies for improving ethnic minority accrual rates in clinical trials.
Participation in cancer clinical trials: race-, sex-, and age-based disparities.
- MedicineJAMA
- 2004
Although the total number of trial participants increased during the study period, the representation of racial and ethnic minorities decreased and were less likely to enroll in cooperative group cancer trials than were whites, men, and younger patients, respectively.