Twenty years of biochemistry of human P450s: purification, expression, mechanism, and relevance to drugs.

@article{Guengerich1998TwentyYO,
  title={Twenty years of biochemistry of human P450s: purification, expression, mechanism, and relevance to drugs.},
  author={F Peter Guengerich and Natilie A Hosea and Asit Parikh and L Chastine Bell-Parikh and William W. Johnson and Elizabeth M J Gillam and Tsutomu Shimada},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={1998},
  volume={26 12},
  pages={1175-8}
}
Today cytochrome P450 (P450) research is accepted as an integral part of drug development and discovery. Work leading to this point included biochemical studies on P450 in experimental animal models and application to human systems. The development of recombinant expression systems has been an important part of the progress, and in this article we describe some recently developed bacterial systems that can be used for the production of metabolites, genotoxicity testing, and screening in random… CONTINUE READING

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