Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer.

@article{Isher2002TwentyyearFO,
  title={Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer.},
  author={B Ernard F Isher and S Tewart A Nderson and Jessica Ryant and R Ichard G. M Argolese and M Elvin D Eutsch and E Dwin R. F Isher and J. Ong and Yeon J Eong and N Orman W Olmark},
  journal={The New England Journal of Medicine},
  year={2002},
  volume={347},
  pages={1233-1241}
}
A BSTRACT Background In 1976, we initiated a randomized trial to determine whether lumpectomy with or without radiation therapy was as effective as total mastectomy for the treatment of invasive breast cancer. [] Key Method Methods A total of 1851 women for whom followup data were available and nodal status was known underwent randomly assigned treatment consisting of total mastectomy, lumpectomy alone, or lumpectomy and breast irradiation.

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