Twenty-four hour rhythms of norepinephrine and serotonin in nucleus suprachiasmaticus, raphe nuclei, and locus coeruleus in the rat.

@article{Semba1984TwentyfourHR,
  title={Twenty-four hour rhythms of norepinephrine and serotonin in nucleus suprachiasmaticus, raphe nuclei, and locus coeruleus in the rat.},
  author={Jun-ichi Semba and Michio Toru and Nobuko Mataga},
  journal={Sleep},
  year={1984},
  volume={7 3},
  pages={
          211-8
        }
}
Twenty-four hour rhythms, at 4 h intervals, of norepinephrine (NE) and serotonin (5-HT) contents were investigated in the rat brain regions where sleep-wakefulness regulation is believed to occur: Nucleus suprachiasmaticus (SC), n. raphe dorsalis (RD) and medialis (RM), and locus coeruleus. Cosinor method of Halberg was applied to evaluate sinusoidal rhythmicity of the measured values. In the SC only NE showed a significant rhythm with a peak value at the beginning of the light period, which… CONTINUE READING

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